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Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study


Autoři: Shoko Tamaki aff001;  Akio Kanazawa aff001;  Junko Sato aff001;  Yoshifumi Tamura aff001;  Takashi Asahara aff003;  Takuya Takahashi aff003;  Satoshi Matsumoto aff003;  Yuichiro Yamashiro aff003;  Hirotaka Watada aff001
Působiště autorů: Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan aff001;  Sportology Center, Juntendo University Graduate School of Medicine, Tokyo, Japan aff002;  Probiotics Research Laboratory, Juntendo University Graduate School of Medicine, Tokyo, Japan aff003;  Yakult Central Institute, Tokyo, Japan aff004;  Center for Therapeutic Innovations in Diabetes, Juntendo University Graduate School of Medicine, Tokyo, Japan aff005;  Center for Identification of Diabetic Therapeutic Targets, Juntendo University Graduate School of Medicine, Tokyo, Japan aff006
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222598

Souhrn

Objective

To explore clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes mellitus (T2DM).

Methods

The data of 118 patients with T2DM were obtained from two previous clinical studies, and were retrospectively analyzed regarding the clinical parameters associated with bacterial translocation defined as detection of bacteremia and levels of plasma lipopolysaccharide binding protein (LBP), the latter of which is thought to reflect inflammation caused by endotoxemia.

Results

LBP level was not significantly different between patients with and without bacteremia. No clinical factors were significantly correlated with the detection of bacteremia. On the other hand, plasma LBP level was significantly correlated with HbA1c (r = 0.312), fasting blood glucose (r = 0.279), fasting C-peptide (r = 0.265), body mass index (r = 0.371), high-density lipoprotein cholesterol (r = -0.241), and inflammatory markers (high-sensitivity C-reactive protein, r = 0.543; and interleukin-6, r = 0.456). Multiple regression analysis identified body mass index, HbA1c, high-sensitivity C-reactive protein, and interleukin-6 as independent determinants of plasma LBP level.

Conclusion

The plasma LBP level was similar in patients with and without bacteremia. While both bacteremia and LBP are theoretically associated with bacterial translocation, the detection of bacteremia was not associated with LBP level in T2DM.

Klíčová slova:

Biology and life sciences – Anatomy – Body fluids – Blood – Blood plasma – Physiology – Biochemistry – Proteins – Hemoglobin – Medicine and health sciences – Blood sugar – Infectious diseases – Bacterial diseases – Bacteremia – Immunology – Immune response – Inflammation – Diagnostic medicine – Signs and symptoms – Diabetes diagnosis and management – HbA1c – Pathology and laboratory medicine – Endocrinology – Endocrine disorders – Metabolic disorders – Research and analysis methods – Mathematical and statistical techniques – Statistical methods – Regression analysis – Physical sciences – Mathematics – Statistics


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