Association between regional brain volumes and BMI z-score change over one year in children


Autoři: Travis D. Masterson aff001;  Carly Bobak aff002;  Kristina M. Rapuano aff003;  Grace E. Shearrer aff004;  Diane Gilbert-Diamond aff001
Působiště autorů: Department of Epidemiology, Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, United States of America aff001;  Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Hanover, New Hampshire, United States of America aff002;  Department of Psychology, Yale University, New Haven, Connecticut, United States of America aff003;  Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0221995

Souhrn

Purpose

Associations between brain region volume and weight status have been observed in children cross-sectionally. However, it is unclear if differences in brain region volume precede weight gain.

Methods

Two high-quality structural brain images were obtained approximately one year apart in 53 children aged 9–12 years old. Children’s height and weight were also measured at each scan. Structural images were processed using the FreeSurfer software-package providing volume measures for regions of interest including the entorhinal cortex, nucleus accumbens, and hippocampus. Age- and sex-adjusted BMI z-scores (BMIz) were calculated at both timepoints. The association between brain region volume and BMIz was examined cross-sectionally using linear regression and longitudinally using structural equation modeling. All models were adjusted by estimated cranial volume to account for individual variation in head size and were corrected for multiple comparisons (pFDR<0.05).

Results

The sample of children was primarily healthy weight at baseline (79.78%). Cross-sectionally at the one-year follow-up, a positive relationship was observed between right hippocampal volume and BMIz (β = 0.43, 95% CI = (0.10, 0.77)). Longitudinally a negative relationship was observed between right entorhinal volume at baseline and BMIz at the one-year follow-up (β = −0.25, 95% CI = (−0.44, −0.07)).

Conclusion

These results suggest that measured volumes from certain regions of the brain that have been associated with BMI in adults are associated with both concurrent BMIz and BMIz change over one-year in a primarily healthy weight sample of children. As the entorhinal cortex integrates signals from both reward and control regions, this region may be particularly important to weight management during child development.

Klíčová slova:

Biology and life sciences – Anatomy – Brain – Cerebral cortex – Entorhinal cortex – Nucleus accumbens – Hippocampus – Physiology – Physiological parameters – Obesity – Childhood obesity – Weight gain – Neuroscience – Neuroimaging – Medicine and health sciences – Body weight – Body Mass Index – Diagnostic medicine – Diagnostic radiology – Magnetic resonance imaging – Radiology and imaging – Research and analysis methods – Imaging techniques


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PLOS One


2019 Číslo 9

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