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Transfusion and Haematology Today

New findings in the pathogenesis of two myelodysplastic syndrome subtypes: 5q- syndrome and sideroblastic anaemia, partially relevant for other onco-haematological diseases

New findings in the pathogenesis of two myelodysplastic syndrome subtypes: 5q- syndrome and sideroblastic anaemia, partially relevant for other onco-haematological diseases

Myelodysplastic syndrome (MDS) is a pre-cancerosis, or rather a pre-leukaemic state. It is not a definitive disease but rather involves heterogeneous clinical manifestations...

Authors: Neuwirtová R., Fuchs O., Jonášová A.
Issue: 4/2012

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The first experience of one center with the use of Octaplas in the treatment of patient with congenital form of TTP

The first experience of one center with the use of Octaplas in the treatment of patient with congenital form of TTP

Congenital form of TTP (Upshaw-Schulman syndrome) is a severe, life-threatening disease in which plasma remains the first-choice treatment. Patients are dependent on regular...

Authors: Čermáková Z., Š. Blahutová, Kořístka M., Hrdličková R.
Issue: 4/2012

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Perioperative management of patients with von Willebrand disease by Wilate – first experiences of one Czech centre

Perioperative management of patients with von Willebrand disease by Wilate – first experiences of one Czech centre

The authors introduce first experiences of their centre with perioperative management of three patients with von Willebrand disease (type 1, type 2 and acquired von Willebrand...

Authors: Hrdličková R., Š. Blahutová, Šimetka O., Zuchnická J., Čermáková Z.
Issue: 4/2012

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The use of natural colloids in fluid resuscitation of severely burned patients

The use of natural colloids in fluid resuscitation of severely burned patients

Objective: The amount of natural colloids (albumin and fresh frozen plasma) administered during fluid resuscitation of burn patients is influenced by many factors. The most...

Authors: Fridrichová L., Lipový B., Brychta P.
Issue: 4/2012

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Supportive therapy with megestrol acetate in myeloproliferative neoplasms

Supportive therapy with megestrol acetate in myeloproliferative neoplasms

We present three cases of patients with myeloproliferative neoplasm that were because of anorexia and weight reduction given megestrol acetate to improve their alimentation and...

Authors: Hubáček J., Faber E., Indrák K.
Issue: 4/2012

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Dasatinib in second line treatment of chronic myeloid leukaemia in patients with imatinib resistance or intolerance treated at the Clinic of Haematology and Transfusiology
Bratislava between 2007 and 2011

Dasatinib in second line treatment of chronic myeloid leukaemia in patients with imatinib resistance or intolerance treated at the Clinic of Haematology and Transfusiology <br> Bratislava between 2007 and 2011

Introduction: Chronic myelogenous leukaemia is the first oncologic disease associated with a concrete chromosomal aberration termed the Philadelphia chromosome, which gives rise...

Authors: Martišová M., Sninská Z., Hatalová A., Demečková E., Mistrík M.
Issue: 3/2012

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Immunosuppressive therapy combining anti-thymocyte globulin and cyclosporine A in childhood acquired aplastic anaemia – long term-outcomes and risks

Immunosuppressive therapy combining anti-thymocyte globulin and cyclosporine A in childhood acquired aplastic anaemia – long term-outcomes and risks

In patients with acquired aplastic anaemia (AA), autoimmunity has been shown to play an important role in the pathogenesis. Therefore immunosuppressive therapy combining...

Authors: Suková M., Mejstříková E., Campr V., Vodičková E., Smíšek P., Keslová P., Sedláček P., Šrámková L., Vávra V., Pindurová E., Zemanová Z., Starý J.
Issue: 3/2012

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Assessment of extramedullary leukemic infiltration in childhood acute lymphoblastic leukemia and its clinical use. Review and original data

Assessment of extramedullary leukemic infiltration in childhood acute lymphoblastic leukemia and its clinical use. Review and original data

Minimal residual disease (MRD) has become a crucial criterion for the risk stratification within modern protocols for the treatment of both childhood and adult acute...

Authors: Volejníková J., Mejstříková E., Slámová L., Mihál V., Štěrba J., Jabali Y., Procházková D., Blažek B., Hak J., Černá Z., Hrušák O., Starý J., Trka J., Froňková E.
Issue: 3/2012

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A rare case of intestinal bleeding in patient with colorectal carcinoma on anticoagulation treatment

A rare case of intestinal bleeding in patient with colorectal carcinoma on anticoagulation treatment

Aim: The authors point to the risk of bleeding in patients with colorectal carcinoma, on the treatment with warfarin. Material and methods: The authors present a case report of...

Authors: Mýtnik M., Petrík J., Jedináková Z.
Issue: 3/2012

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Significance of hepcidin level assessment in the diagnosis of selected types of anaemia in childhood

Significance of hepcidin level assessment in the diagnosis of selected types of anaemia in childhood

Introduction. The peptide hormone hepcidin is the principal factor regulating iron homeostasis. It ensures communication between sites where iron is stored (hepatocytes and...

Authors: Pospíšilová D., Houda J., Holub D., Ludíková B., Mojzíková R., Pospíšilová P., Židová Z., Kapraľová K., Horváthová M., Hajdúch M., Džubák P.
Issue: 2/2012

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