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The microRNAs in an Ancient Protist Repress the Variant-Specific Surface Protein Expression by Targeting the Entire Coding Sequence

The microRNAs in an Ancient Protist Repress the Variant-Specific Surface Protein Expression by Targeting the Entire Coding Sequence

microRNAs (miRNA) have been detected in the deeply branched protist, Giardia lamblia, and shown to repress expression of the family of variant-specific surface proteins (VSPs...

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory
A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

A Compositional Look at the Human Gastrointestinal Microbiome and Immune Activation Parameters in HIV Infected Subjects

HIV progression is characterized by immune activation and microbial translocation. One factor that may be contributing to HIV progression could be a dysbiotic microbiome. We...

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory
 Yeasts: How Many Species Infect Humans and Animals?

Yeasts: How Many Species Infect Humans and Animals?

article has not abstract

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory
Lectin-Like Bacteriocins from  spp. Utilise D-Rhamnose Containing Lipopolysaccharide as a Cellular Receptor

Lectin-Like Bacteriocins from spp. Utilise D-Rhamnose Containing Lipopolysaccharide as a Cellular Receptor

Lectin-like bacteriocins consist of tandem monocot mannose-binding domains and display a genus-specific killing activity. Here we show that pyocin L1, a novel member of this...

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory
The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection

The Major Cellular Sterol Regulatory Pathway Is Required for Andes Virus Infection

The Bunyaviridae comprise a large family of RNA viruses with worldwide distribution and includes the pathogenic New World hantavirus, Andes virus (ANDV). Host factors needed for...

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory
Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF

The essential herpesvirus adaptor protein HVS ORF57, which has homologs in all other herpesviruses, promotes viral mRNA export by utilizing the cellular mRNA export machinery...

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory
Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters

Viral MicroRNA Effects on Pathogenesis of Polyomavirus SV40 Infections in Syrian Golden Hamsters

Effects of polyomavirus SV40 microRNA on pathogenesis of viral infections in vivo are not known. Syrian golden hamsters are the small animal model for studies of SV40. We report...

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory
Foxp3 Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice

Foxp3 Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice

Accumulating evidence suggests that IL-9-mediated immunity plays a fundamental role in control of intestinal nematode infection. Here we report a different impact of Foxp3...

Full article   PLOS Pathogens Issue: 2/2014

Specialization: Hygiene and epidemiology Medical virology Laboratory