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FUS Interacts with HSP60 to Promote Mitochondrial Damage

FUS Interacts with HSP60 to Promote Mitochondrial Damage

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are two groups of common and devastating neurodegenerative diseases, characterized by losses of...

Full article   PLOS Genetics Issue: 9/2015

Specialization: Medical genetics Reproduction medicine
Point Mutations in Centromeric Histone Induce Post-zygotic Incompatibility and Uniparental Inheritance

Point Mutations in Centromeric Histone Induce Post-zygotic Incompatibility and Uniparental Inheritance

The centromeric histone protein, CENH3, plays an important role in chromosome segregation during mitosis and meiosis. Here we show that single amino acid changes in CENH3, while...

Full article   PLOS Genetics Issue: 9/2015

Specialization: Medical genetics Reproduction medicine
A Large-Scale Functional Analysis of Putative Target Genes of Mating-Type Loci Provides Insight into the Regulation of Sexual Development of the Cereal Pathogen

A Large-Scale Functional Analysis of Putative Target Genes of Mating-Type Loci Provides Insight into the Regulation of Sexual Development of the Cereal Pathogen

The production of sexual propagules via a self-fertile mating strategy in Fusarium graminearum, an important cereal pathogen, is essential for overwintering and dissemination...

Full article   PLOS Genetics Issue: 9/2015

Specialization: Medical genetics Reproduction medicine
Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion

Slit-Dependent Endocytic Trafficking of the Robo Receptor Is Required for Son of Sevenless Recruitment and Midline Axon Repulsion

The formation of sterotyped neuronal connections during embryonic development is essential for animal survival and behavior. In particular, establishing proper connectivity at...

Full article   PLOS Genetics Issue: 9/2015

Specialization: Medical genetics Reproduction medicine
Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

Identification of Four Mouse Diabetes Candidate Genes Altering β-Cell Proliferation

Complex genetic determinants contribute to an inherent susceptibility of type 2 diabetes, characterized by insulin resistance, a dysfunction and loss of insulin-producing beta...

Full article   PLOS Genetics Issue: 9/2015

Specialization: Reproduction medicine Medical genetics
Signaling from Within: Endocytic Trafficking of the Robo Receptor Is Required for Midline Axon Repulsion

Signaling from Within: Endocytic Trafficking of the Robo Receptor Is Required for Midline Axon Repulsion

article has not abstract

Full article   PLOS Genetics Issue: 9/2015

Specialization: Medical genetics Reproduction medicine
Signaling from Within: Endocytic Trafficking of the Robo Receptor Is Required for Midline Axon Repulsion

Signaling from Within: Endocytic Trafficking of the Robo Receptor Is Required for Midline Axon Repulsion

article has not abstract

Full article   PLOS Genetics Issue: 9/2015

Specialization: Medical genetics Reproduction medicine
Effects of Sudden Air Temperature and Pressure Changes on Mortality in the Czech Republic

Effects of Sudden Air Temperature and Pressure Changes on Mortality in the Czech Republic

We have developed an algorithm for identifying sudden changes in air pressure and temperature over the Czech Republic. Such events were retrieved from the data covering in 1986...

Full article   Epidemiology, Microbiology, Immunology Issue: 2/2009

Specialization: Medical genetics Reproduction medicine