A occupational preventive health care of workers at risk of cytostatic drugs in the Faculty Hospital Hradec Králové
Authors: Chaloupka J., Boušová K., Bubeníčková J., Rinnová H.
Authors - sphere of activity: Klinika nemocí z povolání LF UK a FN Hradec Králové, přednosta doc. MUDr. Jiří Chaloupka, CSc.
Article: Pracov. Lék., 63, 2011, No. 2, s. 72-78.
Category: Original Papers
Number of articles displayed: 320x
Manipulation with cytostatic drugs and their aplication to patients causes contamination of external environment and long-term professional exposure in health care staff. Carcinogenic, teratogenic effects and reproduction and system toxicity are the possible consequences of the exposure. The method of cytogenetic analysis of peripheral lymphocytes (CAPL) which detects structural and numerical aberations in cultivated peripheral lymphocytes is used as a biomarker of the early biological effect of mutagenic and carcinogenic substances.
In 2006, 2008 and 2010, 150 individuals were examined using the CAPL method in the Faculty Hospital Hradec Králové. The mean values of the number of chromosomal aberrations were 3.04 %, 3.79 % and 3.41 % in respective years indicating increased exposure to genotoxic substances. The lowest values were found in employees of the hospital pharmacy (2.94 %) and the lung clinic (3.04 %). Higher values were found in employees of children hematooncology (3.64 %) and the clinic of oncology and radiotherapy (3.62 %). Higher values were found in smokers compared to nonsmokers. Results are considered as a nonspecific complex indicator influenced with a number of factors (level of exposure, activity of reparatory mechanisms, activity of immune system, susceptibility to genotoxic substances, life style factors, etc.). It is necessary to take measures to decrease the exposure of employees in order to reduce health risks.
cytostatic drugs, facility health care, cytogenetic analysis of peripheral lymphocytes, chromosomal aberrations, health care system
The full wording of this article is available only to registered users. Plese register and you can read this article immediately.
If you are a subscriber, log in and enter the subscriber code from your magazine cover.
If you are not a subscriber, log in for unlimited access to older editions.
Tento článek si můžete přečíst pokud si aktivujete Premium účet.
Selection of CzMA JEP journals
- Evaluation of psychical workload in occupations of Social Care Homes, Hospital-Policlinic Institutions and Selected Non-medical Areas | views: 42
- Work satisfaction in general nurses in the Czech Republic according to value distances | views: 26
- Occupational asthma and occupational rhinitis – one airway tract, one disease? | views: 19
- Attention: ozone! | views: 13