Alzheimer’s Disease Manifesting as Corticobasal Degeneration – Case Report
Authors: S. Johanidesová, R. Rusina, P. Houška, J. Keller, R. Matěj
Authors - sphere of activity: 1Neurologická klinika IPVZ a Thomayerova nemocnice, Praha; 2Neurologické oddělení, Nemocnice Strakonice, a.s.; 33. LF UK v Praze; 4Radiodiagnostické oddělení, Nemocnice na Homolce, Praha; 5Oddělení patologie a molekulární medicíny, Thomayerova nemocnice, Praha
Article: Cesk Slov Neurol N 2012; 75/108(3): 373-377
Category: Case Report
Number of articles displayed: 553x
Corticobasal degeneration is a rare neurodegenerative disease that belongs to the group of tauopathies is clinically manifested as a combination of extrapyramidal symptoms and cortical dysfunction affecting mainly the parietal areas. The definite diagnosis of corticobasal degeneration is based on neuropathological findings. For this reason, the term corticobasal syndrome tends to be used in surviving patients. The objective of our paper is to present a case of a patient with corticobasal syndrome as a peculiar manifestation of neuropathologically confirmed Alzheimer’s disease. Our patient showed significant cognitive impairment in visuospatial functions, apparent apraxia, frontal signs as well as early episodic memory impairment. Asymmetrical extrapyramidal features with left-sided prevalent akinesia and rigidity, apraxia on the left upper extremity and occasional myoclonus were also present. The pattern of neuropathological changes met the criteria of a fully developed neocortical stage of an early Alzheimer’s disease without any evidence of corticobasal degeneration. The main features evoking Alzheimer’s disease-associated corticobasal syndrome and enabling its differentiation from corticobasal degeneration were lower age at onset and myoclonus. In contrast to previously published data, our patient presented with an early episodic memory impairment suggesting a predominant involvement of the hippocampal and entorhinal
corticobasal syndrome – corticobasal degeneration – Alzheimer’s disease – tauopathies
The full wording of this article is available only to registered users. Plese register and you can read this article immediately.
If you are a subscriber, log in and enter the subscriber code from your magazine cover.
If you are not a subscriber, log in for unlimited access to older editions.
Tento článek si můžete přečíst pokud si aktivujete Premium účet.
- Creutzfeldt-Jacob disease | views: 121
- Spinocerebellar Ataxia 7 – a Case Report | views: 56
- Electrophysiological Examination of the Pelvic Floor | views: 44
- Ultrasound-guided Brain Cavernoma Surgery | views: 42
- Differences in the Modulation of Cortical Activity in Patients Suffering from Upper Arm Spasticity Following Stroke and Treated with Botulinum Toxin A | views: 34
- Torticollis at Grisel’s Syndrome – Case Reports | views: 27
- X-adrenoleukodystrophy | views: 24
- Significance and Limitations of Visual Evoked Potentials in the Study of Pathophysiology of Migraine | views: 23
- Evaluation of Epidemiological Stroke Data from the IKTA Register. Stroke Incidence in the Zlin District | views: 23
- The Role of a Neurootologist in Identification of Post-radiation Complications in Patients with Vestibular Schwannoma Treated with Leksell Gamma Knife | views: 18