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The Role of Chemotherapy in the Treatment of Low-grade Gliomas

The Role of Chemotherapy in the Treatment of Low-grade Gliomas

Background: The standard postsurgical options for low-grade gliomas include watchful waiting or radiotherapy depending on the risk factors for recurrence. The use of...

Full article   Clinical Oncology Issue: 5/2017

Specialization: Clinical oncology Surgery Paediatric clinical oncology
Evaluation of Anti-cancer Therapies with Reimbursement Limited to Comprehensive Cancer Centres Using the European Society for Medical Oncology Magnitude of Clinical Benefit Scale

Evaluation of Anti-cancer Therapies with Reimbursement Limited to Comprehensive Cancer Centres Using the European Society for Medical Oncology Magnitude of Clinical Benefit Scale

Background: The costs of oncology treatments are increasing, due to the rising prevalence of malignant diseases and the introduction of expensive novel anti-cancer agents. The...

Full article   Clinical Oncology Issue: 5/2017

Specialization: Paediatric clinical oncology Surgery Clinical oncology
Isocitrate Dehydrogenase Mutations are Better Prognostic Marker than O<sup>6</sup>-methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastomas – a Retrospective, Single-centre Molecular Genetics Study of Gliomas

Isocitrate Dehydrogenase Mutations are Better Prognostic Marker than O6-methylguanine-DNA Methyltransferase Promoter Methylation in Glioblastomas – a Retrospective, Single-centre Molecular Genetics Study of Gliomas

Background: Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2) are a promising prognostic biomarker of gliomas. The purpose of our study was to examine the clinical...

Full article   Clinical Oncology Issue: 5/2017

Specialization: Paediatric clinical oncology Surgery Clinical oncology
The Anti-apoptotic Mechanism of Metformin Against Apoptosis Induced by Ionizing Radiation in Human Peripheral Blood Mononuclear Cells

The Anti-apoptotic Mechanism of Metformin Against Apoptosis Induced by Ionizing Radiation in Human Peripheral Blood Mononuclear Cells

Background: In a previous article, we showed that metformin (MET) can reduce ionizing radiation (IR) induced apoptosis in human peripheral blood mononuclear cells. However, the...

Full article   Clinical Oncology Issue: 5/2017

Specialization: Clinical oncology Surgery Paediatric clinical oncology
Treatment Refusal in Pediatric Oncology

Treatment Refusal in Pediatric Oncology

Background: Pediatric oncologists are often faced with situations in which parents or guardians refuse recommended treatment for curable childhood cancer. Deciding how to...

Full article   Clinical Oncology Issue: 5/2017

Specialization: Clinical oncology Surgery Paediatric clinical oncology
Potential of Using Vitamin D as an Adjuvant Treatment of Malignant Melanoma

Potential of Using Vitamin D as an Adjuvant Treatment of Malignant Melanoma

The incidence of malignant melanoma worldwide continues to grow despite the enormous advances in topical and systemic therapy. This increase is recorded regularly even in...

Full article   Clinical Oncology Issue: 5/2017

Specialization: Paediatric clinical oncology Surgery Clinical oncology
Controversy in the Postoperative Treatment of Low-grade Gliomas

Controversy in the Postoperative Treatment of Low-grade Gliomas

Background: The optimal treatment for low-grade gliomas remains controversial. Neurosurgery, radiotherapy, and chemotherapy are the main treatment options. Despite advances in...

Full article   Clinical Oncology Issue: 5/2017

Specialization: Paediatric clinical oncology Surgery Clinical oncology
Novel Findings in Follicular Lymphoma Pathogenesis  and the Concepts of Targeted Therapy

Novel Findings in Follicular Lymphoma Pathogenesis and the Concepts of Targeted Therapy

The molecular pathogenesis of follicular lymphoma (FL) was partially revealed by the discovery of BCL2 translocations to the region encoding the immunoglobulin heavy chain...

Full article   Clinical Oncology Issue: 4/2017

Specialization: Paediatric clinical oncology Surgery Clinical oncology
Confocal Laser Endomicroscopy in the Diagnostics of Malignancy of the Gastrointestinal Tract

Confocal Laser Endomicroscopy in the Diagnostics of Malignancy of the Gastrointestinal Tract

In confocal laser endomicroscopy (CLE), a type of optical microscope that uses a laser beam as its light source and processes the acquired image by processor unit is used...

Full article   Clinical Oncology Issue: 4/2017

Specialization: Paediatric clinical oncology Surgery Clinical oncology
Reactive Lymphoid Hyperplasia of the Liver

Reactive Lymphoid Hyperplasia of the Liver

Case: Here, we present the case of a 50-year-old woman diagnosed with stage I hormone-dependent breast cancer. The patient underwent partial mastectomy followed by adjuvant...

Full article   Clinical Oncology Issue: 4/2017

Specialization: Paediatric clinical oncology Surgery Clinical oncology