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Number of results: 22410

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Influence of smoking and free radicals on antioxidant defence and on the pathogenesis of certain diseases

Cigarette smoke leads to the production of a large number of different free radicals, especially superoxide, alkoxy- and alkyl- radicals and free hydroxyl radicals. Antioxidant defence must be complex, i.e. a mixture of different substances. Smoking injures intracellular antioxidant balance...

Source: General Practitioner
Issue: 1 / 2008
Authors: HOLEČEK V., ROKYTA R.
Number of articles displayed: 1527x

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Ethics committees in the Czech Republic

Ethics committees are relatively new phenomena in the Czech Republic. From the history of the origin of ethics committees and the development of their roles, it is possible to document the function of certain ethical mechanisms in society. Ethics committees were established according to the...

Source: General Practitioner
Issue: 1 / 2008
Authors: ŠIMEK J., ZAMYKALOVÁ L., MESANYOVÁ M.
Number of articles displayed: 997x

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Skin examination by high-frequency ultrasound

The introduction of high frequency ultrasound scanners has made it possible for non-invasive technology to be used in dermatology. It is possible to create an image of the skin’s structure by means of ultrasonic waves and computer technology, which is of use in research, diagnostics and follow...

Source: General Practitioner
Issue: 1 / 2008
Authors: RESL V., LEBA M., RAMPL I., ŘÍČAŘ J.
Number of articles displayed: 1232x

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Diagnostic problems of non-alcoholic steatohepatitis in clinicopathological practice

Non-alcoholic fatty liver disease (NAFLD) has recently become one of the most frequent and most important hepatic disorders throughout the world. This complex clinicopathological condition includes a spectrum of several nosological entities with distinct prognosis. The mildest form is a simple...

Source: General Practitioner
Issue: 1 / 2008
Authors: BARTOŠ V., SLÁVIK P., KRKOŠKA D.
Number of articles displayed: 3045x

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Clinical aspects and neurobiology of vascular dementia

The first book on vascular dementia (VD) is more than 450 years old; nevertheless epidemiology, signs and symptoms, pathogenesis, prevention and therapy of VD are currently discussed more than ever. The clinical research uses several types of diagnostic criteria of VD (e.g. ICD-10, DSM-IV, NINCDS...

Source: General Practitioner
Issue: 1 / 2008
Authors: KOUKOLÍK, F.
Number of articles displayed: 1523x

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Febrile infections in travellers returning from the tropics

Travel medicine is a dynamically evolving medical speciality. As the number of Czech tourists travelling to tropical regions is increasing, more and more general practitioners are seeing and treating these patients. Since there is also an increasing number of immigrants from tropical countries...

Source: General Practitioner
Issue: 1 / 2008
Authors: STEJSKAL F.
Number of articles displayed: 1409x

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Combination of paclitaxel + gemcitabine as a salvage therapy in patients with germ cell tumors.

Roughly 20% of patients with advanced GCT relapse or fail to achieve a complete response to conventional cis-platin based chemotherapy. Patients (pts) with relapsed or refractory GCT may be cured by salvage chemotherapy with gemcitabine and paclitaxel. 38 consecutive pts were treated with...

Source: General Practitioner
Issue: 1 / 2008
Authors: FOLDYNA M., ABRAHÁMOVÁ J., NEPOMUCKÁ J., KORDÍKOVÁ D.
Number of articles displayed: 1442x

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Causal treatment options for lower extremity varices

By way of introduction, the article reviews the pathophysiology of lower extremity varices and outlines current methods of examination. All the possible treatment options (from minimally invasive therapy to complex stripping) are discussed based on the pathophysiological genesis. The correct...

Source: General Practitioner
Issue: 1 / 2008
Authors: DITL P., VAŠINA T., ŠONSKÝ E., ANTOŠ F.
Number of articles displayed: 1505x

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The role of the general practitioner and the occupational disease specialist in diagnosis of occupational asthma and occupational rhinitis

The aim of the study is to provide more information about occupational asthma and occupational rhinitis from both the health and also the socio-economic point of view and to emphasize the role of co-operation between general practitioner and specialist for occupational diseases. Authors present...

Source: General Practitioner
Issue: 1 / 2008
Authors: Lebedová J., Fenclová Z., Klusáčková P., Dlouhá B., Navrátil T., Hurtová L.
Number of articles displayed: 1030x

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Smoking Helpline service – an important programme in the fight against tobbaco addition

A “Quitline” is an important part of the spectrum of services provided to help treat tobacco dependence. The Czech Quitline was set up on January the 1st, 2005, and is operated daily between 12pm and 8pm. It is run by specially trained medical students from all three Prague medical schools...

Source: General Practitioner
Issue: 1 / 2008
Authors: LANGROVÁ K., KRÁLÍKOVÁ E., VOJTA M.
Number of articles displayed: 1052x

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Dynamics of oncomarkers duringthe oncological treatment of testicular germinal cell tumours

Testicular germ cell tumours (GCT) are highly curable though require proper management at all stages. GCTs are classified in two major subgroups: seminoma and non-seminoma. Serum concentrations of tumour markers – AFP, LDH and beta-HCG – are an integral part of the TNM classification system...

Source: General Practitioner
Issue: 1 / 2008
Authors: DONÁTOVÁ Z., ABRAHÁMOVÁ J., MALBOHAN I., FOLDYNA M., NEPOMUCKÁ J.
Number of articles displayed: 1462x

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Transparent accountability in medicine and responsibility of ethics committees.

This paper is a reflection on the meaning of the term “accountability”, which is connected with the concepts of responsibility, trust and transparency. The authors present certain situations in pharmacology research that require responsibility of actions in conjunction with transparency of...

Source: General Practitioner
Issue: 2 / 2008
Authors: ZAMYKALOVÁ L., ŠIMEK J.
Number of articles displayed: 556x

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Current possibilities and problems of antiretroviral therapy

The introduction of antiretroviral therapy to clinical practice has assured a significant improvement in the quality of life for people living with HIV infection, and has substantially prolonged their life expectancy. At present there are four classes of antiviral drugs in clinical use and...

Source: General Practitioner
Issue: 2 / 2008
Authors: MACHALA L., JILICH D.
Number of articles displayed: 616x

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Insights into the pathogenesis of autism spectrum disorders from the molecular and cellular level

Despite the great array of observations, the etiopathogenesis of the autism spectrum disorders (ASD) is poorly defined. Our review offers evidence that most heterogeneous symptoms of ASD might have a common set of pathophysiological events at cellular level closely connected with dysregulation of...

Source: General Practitioner
Issue: 2 / 2008
Authors: STRUNECKÁ A., BLAYLOCK R.L.
Number of articles displayed: 615x

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Memory and its disturbances

The memory in the human brain is not a unified system. Widely accepted classification discerns short-term working memory, long-term conscious declarative memory (semantic and episodic) and several types of non-conscious memories: procedural (habit), priming, pavlovian conditioning and emotional...

Source: General Practitioner
Issue: 2 / 2008
Authors: KOUKOLÍK, F.
Number of articles displayed: 759x

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Metallothionein and its relation to anticancer treatment by platinum complexes

Metallothionein: It is a small protein with high content of cysteine, whose sulfhydryl groups give metallothionein its unique properties. In organism metallothionein transports metal ions (Zn, Cu), but it can even bind and eliminate toxic metal ions (Cd, Pb, Hg, etc.). Metallothionein helps to...

Source: General Practitioner
Issue: 2 / 2008
Authors: Fabrik I., Kukačka J., Adam V., Průša R., Eckschlager T., Kizek R.
Number of articles displayed: 609x

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Left atrial structural remodelling and restoration of atrial contraction after successful thoracoscopic epicardial microwave pulmonary vein isolation.

Aim: Atrial fibrillation (AF) is accompanied by the lack of contractile function and successive progression of atrial volumes. Endoscopic microwave pulmonary isolation represents a new technique of AF ablation (the isolation of pulmonary veins by epicardial approach). The aim of the study was to...

Source: General Practitioner
Issue: 2 / 2008
Authors: PEROUTKA Z., STRAKA Z., OSMANČÍK P., PĚNIČKA M., LÍNKOVÁ H., HEROLD M.
Number of articles displayed: 614x

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The hoarding of possessions and animals

Extreme hoarding of possessions and animals resulting in the obstruction of a household occurs in several mental disorders, namely in organic and obsessive-compulsive disorders. This compulsive hoarding has clinical features and can be treated. Key-words: hoarding, senior self-neglect, obsessive...

Source: General Practitioner
Issue: 2 / 2008
Authors: CHROMÝ K.
Number of articles displayed: 854x

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Current strategy to pneumococcal conjugate vaccine immunization

Streptococcus pneumoniae causes diversiform scale of various diseases in childhood ranging from the most serious invasive like meningitis and septicemias (bacteriemias) through pneumonias up to life as a rule not threatening but all the more frequent acute otitis and sinusitis. Incidence of...

Source: General Practitioner
Issue: 2 / 2008
Authors: PRYMULA R., POSPÍŠILOVÁ K.
Number of articles displayed: 598x

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Acute toxic hepatitis following consumption of a herbal preparation

Acute toxic hepatitis can be induced by a range of drugs, it can also occur after the consumption of herbal preparations. We present a case of acute toxic hepatitis following the use of a herbal food supplement for the treatment of psoriasis. It is widely recognised that conventional medications...

Source: General Practitioner
Issue: 2 / 2008
Authors: HEJLOVÁ I., ŠPERL J., FRAŇKOVÁ S., KAMENÁŘ D., STICOVÁ E., ŠPIČÁK J.
Number of articles displayed: 741x

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