Přihlášení

Přihlášený uživatel: . Nejste to Vy? Přihlašte se pod svým e-mailem.

Zadejte prosím své heslo do proLékaře.cz, abychom ověřili, že jste to opravdu Vy.

 
Aktuální číslo
Archiv čísel
Informace o časopisu
Redakční rada
Redakce
Předplatné
Pokyny pro autory a recenzenty
Kontakt
 

BMC Medicine

Genetic variation in <i>Mycobacterium tuberculosis</i> isolates from a London outbreak associated with isoniazid resistance

Genetic variation in Mycobacterium tuberculosis isolates from a London outbreak associated with isoniazid resistance

Background There has been a global increase in isoniazid (INH)-resistant (INH-R) tuberculosis (TB) [1]. This is important because INH resistance reduces the chance of successful...

Celý článek   BMC Medicine Číslo: 117/2016

Specializace: interní lékařství pneumologie a ftizeologie
Antimicrobial agents – optimising the ecological balance

Antimicrobial agents – optimising the ecological balance

Background The discovery of penicillin brought great hope for the treatment of infectious diseases. However, two decades later, in the late 1940s, acceptance, mass production...

Celý článek   BMC Medicine Číslo: 114/2016

Specializace: hygiena a epidemiologie zdravotnictví
 
 
The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact

The global threat of Zika virus to pregnancy: epidemiology, clinical perspectives, mechanisms, and impact

Background Zika virus (ZIKV) infection was previously considered to be of modest public health concern, causing only mild fever, rash, and arthralgia in 20 % of patients, with...

Celý článek   BMC Medicine Číslo: 112/2016

Specializace: dětská neurologie infekční lékařství neonatologie neurologie
Frugal innovation in medicine for low resource settings

Frugal innovation in medicine for low resource settings

Background The story goes that Laennec, who was embarrassed to put his ear on the chest of a young woman, used a sheaf of paper rolled into a cylinder to auscultate the heart...

Celý článek   BMC Medicine Číslo: 102/2016

No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Background Non-alcoholic fatty liver disease (NAFLD) is the most common cause of liver disease worldwide [1], with an estimated prevalence of 20 % in the general population and...

Celý článek   BMC Medicine Číslo: 92/2016

Beyond viral suppression of HIV – the new quality of life frontier

Beyond viral suppression of HIV – the new quality of life frontier

Introduction In May 2016, in its 69th session, the World Health Assembly approved a new Global Health Sector Strategy on HIV for 2016–2021 [1]. The goal of the strategy is...

Celý článek   BMC Medicine Číslo: 94/2016

How important is gametocyte clearance after malaria therapy?

How important is gametocyte clearance after malaria therapy?

Background Global improvements in malaria control over the last 15 years have been greater than at any other time in history, with annual deaths from malaria having almost...

Celý článek   BMC Medicine Číslo: 93/2016

Antibiotic use during pregnancy: how bad is it?

Antibiotic use during pregnancy: how bad is it?

Background The human body is home to a variety of microorganisms, termed the microbiota, consisting of up to 100 trillion bacterial cells, most of which reside in the gut. Large...

Celý článek   BMC Medicine Číslo: 91/2016

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

Potential of immunomodulatory agents as adjunct host-directed therapies for multidrug-resistant tuberculosis

Background The World Health Organization (WHO) presently ranks tuberculosis (TB) as the leading cause of death due to infectious disease worldwide, with an estimated 1.5 million...

Celý článek   BMC Medicine Číslo: 89/2016

The gut microbiome in human immunodeficiency virus infection

The gut microbiome in human immunodeficiency virus infection

Background Since the emergence of the acquired immunodeficiency syndrome (AIDS) epidemic in the early 1980s and the discovery of its causative agent, the human immunodeficiency...

Celý článek   BMC Medicine Číslo: 83/2016

Benefits of the Mediterranean diet beyond the Mediterranean Sea and beyond food patterns

Benefits of the Mediterranean diet beyond the Mediterranean Sea and beyond food patterns

Background The huge toll of death and disability caused each year by cardiovascular disease (CVD) continues to represent a great humiliation for public health. More people die...

Celý článek   BMC Medicine Číslo: 157/2016

Ethical issues in microbiome research and medicine

Ethical issues in microbiome research and medicine

Background The cohabitation of the human genome and the genomes of the bacteria and viruses that occupy our skin, mucous membranes, intestinal tract, and other parts of our...

Celý článek   BMC Medicine Číslo: 156/2016

Medicine shortages: a commentary on causes and mitigation strategies

Medicine shortages: a commentary on causes and mitigation strategies

Background Shortages of medicines and vaccines have been reported in countries of all income levels in recent years. For example, in 2013, Kerala, India, faced a shortage of 130...

Celý článek   BMC Medicine Číslo: 124/2016

Reporting studies on time to diagnosis: proposal of a guideline by an international panel (REST)

Reporting studies on time to diagnosis: proposal of a guideline by an international panel (REST)

Background Time to diagnosis (TTD) is the interval from first alert symptoms to the diagnosis of a disease in a patient [1, 2, 3]. Studies on TTD may aim at (1) measuring the...

Celý článek   BMC Medicine Číslo: 146/2016

Probiotics and microbiota composition

Probiotics and microbiota composition

Background The consumption of probiotics has been reported to induce a range of benefits for human health, including the prevention of necrotizing enterocolitis in premature...

Celý článek   BMC Medicine Číslo: 82/2016

The importance of collecting structured clinical information on multiple sclerosis

The importance of collecting structured clinical information on multiple sclerosis

An introduction to real-world evidence (RWE) in multiple sclerosis (MS) In general, randomised controlled trials (RCTs) and RWE studies are important for improving our...

Celý článek   BMC Medicine Číslo: 81/2016

Flexible, dual-form nicotine replacement therapy or varenicline in comparison with nicotine patch for smoking cessation: a randomized controlled trial

Flexible, dual-form nicotine replacement therapy or varenicline in comparison with nicotine patch for smoking cessation: a randomized controlled trial

Background Despite the well-established consequences [1], smoking remains prevalent worldwide [1, 2, 3]. Cessation attempts are common; 40 % of smokers try to quit at least...

Celý článek   BMC Medicine Číslo: 80/2016

Contact heat sensitivity and reports of unpleasantness in communicative people with mild to moderate cognitive impairment in Alzheimer’s disease: a cross-sectional study

Contact heat sensitivity and reports of unpleasantness in communicative people with mild to moderate cognitive impairment in Alzheimer’s disease: a cross-sectional study

Background Poorly managed pain in people with Alzheimer’s disease (AD) is a significant public health concern. AD in general is a risk factor for the under-treatment of pain...

Celý článek   BMC Medicine Číslo: 74/2016

Antibiotics, obesity and the link to microbes - what are we doing to our children?

Antibiotics, obesity and the link to microbes - what are we doing to our children?

Background The increasing prevalence of childhood obesity is one of the greatest challenges facing medical professionals caring for infants and children. According to a recent...

Celý článek   BMC Medicine Číslo: 57/2016

Incorporation of tissue-based genomic biomarkers into localized prostate cancer clinics

Incorporation of tissue-based genomic biomarkers into localized prostate cancer clinics

Background Prostate cancer (PCa) represents the most commonly diagnosed internal malignancy among men in the Western world. In 2015, the number of men diagnosed with PCa was...

Celý článek   BMC Medicine Číslo: 67/2016

Rationing tests for drug-resistant tuberculosis – who are we prepared to miss?

Rationing tests for drug-resistant tuberculosis – who are we prepared to miss?

Background Among notified patients with pulmonary tuberculosis (TB) in 2014, the estimated total number of cases of multidrug-resistant TB (MDR-TB) worldwide was 480,000, of...

Celý článek   BMC Medicine Číslo: 30/2016

HbA<sub>1c</sub> levels in non-diabetic older adults – No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies

HbA1c levels in non-diabetic older adults – No J-shaped associations with primary cardiovascular events, cardiovascular and all-cause mortality after adjustment for confounders in a meta-analysis of individual participant data from six cohort studies

Background Glycated hemoglobin (HbA1c) is a biomarker for impaired glucose metabolism and indicates the average blood glucose concentration over the previous 2–3 months [1...

Celý článek   BMC Medicine Číslo: 26/2016

Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Fatigue is associated with excess mortality in the general population: results from the EPIC-Norfolk study

Background Fatigue is a normal experience, but for some persons its impact is profound, resulting in concerns regarding their health. In fact, fatigue is one of the commonest...

Celý článek   BMC Medicine Číslo: 122/2016

Evaluation in alcohol use disorders – insights from the nalmefene experience

Evaluation in alcohol use disorders – insights from the nalmefene experience

Search strategy and selection criteria In this review of published and unpublished literature, we looked for evidence, including clinical studies (completed, terminated or...

Celý článek   BMC Medicine Číslo: 119/2016

 
 
 
 
 
 

diskuze